Long Cai receives NIH Director's Pioneer Award
Oct 6, 2022
NIH has announced Long Cai is a recipient of its prestigious Pioneer Award. This award from the High-Risk, High Reward Research Program supports individual s...
read moreCai Lab
We have pioneered the field of single cell spatial genomics, gaining unprecedented insights into the molecular and spatial organization of organisms.
What drives us?
Biology is defined by spatial organization at many scales, ranging from meters – the size of the human body – to nanometers (billionths of a meter) – the size of molecules. We develop and utilize breakthrough technologies that allow us to observe the organization inside cells and the processes that drive cell functions.
Our methods answer the technical challenge of how to comprehensively image cell activity within its native environment. We’re able to apply our technologies to some of the most challenging problems in developmental biology, immunology, neuroscience, cancer biology, and microbiology.
Learn more about us
Our Technologies
Cai Lab developed seqFISH, a novel imaging technology that allows us to simultaneously visualize tens of thousands of different molecules in a single tissue sample. To achieve this level of molecular information, we combine fluorescence microscopy, DNA labeling nanotechnology, custom fluid handling, and advanced image processing.
In collaboration with the Elowitz Lab at Caltech, we’ve developed MEMOIR – a system that allows us to record cell lineage information and event histories in vivo that can subsequently be readout in situ by seqFISH.
Discover seqFISHLatest News
Cai Lab BBQ 2022
Apr 26, 2022
Spring is in full swing on the Caltech campus and Cai Lab is celebrating! Leaving our bench work behind, the whole team had a much needed break beneath the t...
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News feature: Revealing chromosome contours, one dot at a time
Feb 21, 2022
Nature interviews Cai Lab in this week's Technology Feature. In a vivid review article, Long Cai, along with Mitch Guttman (Caltech) and peers, describe how ...
read moreThe Cai Lab Team
We are a group of scientists with diverse research interests who are working together to uncover new biological principles using the power of multiplexed molecular imaging in single cells/in situ.
Meet the teamConnect With Us
We are excited to hear from you. If you have any questions about our work, our lab, or want to collaborate, please send us a message.
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